Controlled Release: s-Adenosyl-Methionine-Disulfate-Tosylate
SAMe has been used in over twenty clinical trials for depression. It has produced similar results to pharmaceutical drugs without the same degree of side effects. According to psychiatrist Richard Brown, M.D., SAMe patients usually see response within a few days. Dr. Brown recommends starting with 400mg per day in single or divided doses on an empty stomach. If results are not seen within two weeks, he recommends increasing the dosage to 800mg in divided doses. In Germany, SAMe is approved as an arthritis treatment. Clinical trials with over 20,000 patients have demonstrated excellent results. SAMe has been shown to be very important in the production of cartilage. These results have been confirmed by MRI in patients with hand osteoarthritis. Typical dosage is 400 mg TID. In a placebo controlled fibromyalgia study, forty-four patients, those taking 800mg SAMe for six weeks experienced reduced stiffness, tenderness, and depression compared with the placebo. In another study with forty-seven fibromyalgia patients, SAMe reduced pain and improved sleep. In addition, SAMe is useful at treating liver disorders such as hepatitis, cirrhosis, and elevated serum bilirubin levels including Gilbert’s Syndrome. SAMe is known to be involved in over 40 biochemical reactions in the body. It is extracted from the amino acid methionine; SAMe influences brain chemicals by helping convert norepinephrine to epinephrine and serotonin to melatonin. It helps make glutathione, the body’s premier detoxifying antioxidant (which is poorly absorbed if taken directly). SAMe can be enhanced by supplementing with B12, folic acid, and methionine. SAMe must be carefully stored and processed. Enteric coated tablets preserve freshness and stability. Production and storage must be done at low heat. It should not be encapsulated. Health Concerns SAMe is the same as used in European studies which is different from over the counter brands. Health Concerns SAMe is one of few that have been researched. Care is taken in our manufacturing process to prevent contact with moisture. We avoid blister packaging which exposes the product to damaging high heat.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious condition.